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Maintenance of genome integrity is essential to prevent cancer. Genotoxic stress drives damaged DNA out of the nucleus by forming micronuclei. Two studies in Nature reveal how the cytosolic DNA… Click to show full abstract
Maintenance of genome integrity is essential to prevent cancer. Genotoxic stress drives damaged DNA out of the nucleus by forming micronuclei. Two studies in Nature reveal how the cytosolic DNA sensor cGAS gains access to the cargo within micronuclei to drive type I IFN responses.
Keywords:
manages genotoxic;
micro manages;
cgas micro;
stress;
genotoxic stress
Journal Title: Immunity
Year Published: 2017
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Journal Title: Immunity
Year Published: 2017
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!