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Better Together: B7S1 Checkpoint Blockade Synergizes with anti-PD1.

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T cell checkpoint blockades can produce durable clinical responses, but only some patients and cancer types respond. In this issue of Immunity, Li et al. (2018) show B7S1-B7S1R signaling additionally regulates… Click to show full abstract

T cell checkpoint blockades can produce durable clinical responses, but only some patients and cancer types respond. In this issue of Immunity, Li et al. (2018) show B7S1-B7S1R signaling additionally regulates CD8+ T cell responses by working with the PD1-PDL1 checkpoint to block anti-tumor immunity.

Keywords: pd1; better together; checkpoint blockade; together b7s1; checkpoint; b7s1 checkpoint

Journal Title: Immunity
Year Published: 2018

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