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What Came First: The Microbiota or the Tr(egg) Cells?

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Studies have shown that gut commensals facilitate the differentiation of peripheral regulatory T cells (pTregs) via their metabolic products. In this issue of Immunity, Campbell et al. (2018) demonstrate a reciprocal effect… Click to show full abstract

Studies have shown that gut commensals facilitate the differentiation of peripheral regulatory T cells (pTregs) via their metabolic products. In this issue of Immunity, Campbell et al. (2018) demonstrate a reciprocal effect of pTregs on the metabolic functions of specific gut commensals that affects their overall energy harvest capacity.

Keywords: microbiota egg; first microbiota; egg cells; came first

Journal Title: Immunity
Year Published: 2018

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