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Ion Man: GSDMD Punches Pores to Knock Out cGAS.

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The pore-forming protein GSDMD promotes cytokine release and induces pyroptotic cell death. In this issue of Immunity, Banerjee et al. (2018) document how GSDMD triggers potassium efflux to inhibit cGAS-STING and… Click to show full abstract

The pore-forming protein GSDMD promotes cytokine release and induces pyroptotic cell death. In this issue of Immunity, Banerjee et al. (2018) document how GSDMD triggers potassium efflux to inhibit cGAS-STING and prevent damaging interferon production after bacterial infection.

Keywords: punches pores; ion man; man gsdmd; pores knock; gsdmd punches; gsdmd

Journal Title: Immunity
Year Published: 2018

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