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Bonds Voyage! A Dissociative Model of TCR-CD3 Triggering Is Proposed.

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How the T cell receptor (TCR)-CD3 complex activates T cells is debated. In this issue of Immunity, Brazin et al. (2018) propose that TCR engagement under force releases the CD3 signaling modules to… Click to show full abstract

How the T cell receptor (TCR)-CD3 complex activates T cells is debated. In this issue of Immunity, Brazin et al. (2018) propose that TCR engagement under force releases the CD3 signaling modules to disperse and adopt signaling active states.

Keywords: cd3; model tcr; tcr cd3; dissociative model; bonds voyage; voyage dissociative

Journal Title: Immunity
Year Published: 2018

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