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Recasting the Tissue-Resident Lymphocyte in Celiac Disease.

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In a recent issue of Cell, Mayassi et al. (2019) show that chronic inflammation in celiac disease (CeD) patients changes the repertoire and functional phenotype of intestinal TCR γδ+ intraepithelial lymphocytes.… Click to show full abstract

In a recent issue of Cell, Mayassi et al. (2019) show that chronic inflammation in celiac disease (CeD) patients changes the repertoire and functional phenotype of intestinal TCR γδ+ intraepithelial lymphocytes. These changes are not reversed by gluten-free dietary regimens, suggesting that they might underlie the long-term sensitivity of CeD patients to gluten.

Keywords: resident lymphocyte; recasting tissue; tissue resident; celiac; celiac disease

Journal Title: Immunity
Year Published: 2019

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