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B Cells Hit a Class Ceiling in the Germinal Center.

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Class-switch recombination (CSR) provides diverse effector functions to B cells. In this issue of Immunity, Roco et al. (2019) refute long-standing dogma that germinal centers are the principal location for CSR;… Click to show full abstract

Class-switch recombination (CSR) provides diverse effector functions to B cells. In this issue of Immunity, Roco et al. (2019) refute long-standing dogma that germinal centers are the principal location for CSR; instead, CSR predominantly occurs early post immunization and declines during germinal center formation.

Keywords: germinal center; cells hit; class; class ceiling; hit class

Journal Title: Immunity
Year Published: 2019

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