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Integrating transcriptomic, proteomic, and metabolomic data, Lercher et al. show in a mouse model of LCMV infection that type I interferon alters the expression and function of key enzymes of the… Click to show full abstract
Integrating transcriptomic, proteomic, and metabolomic data, Lercher et al. show in a mouse model of LCMV infection that type I interferon alters the expression and function of key enzymes of the urea cycle in hepatocytes. This results in altered systemic metabolism, attenuating antiviral T cell responses and ameliorating liver injury.
Keywords:
induced interferon;
interferon;
urea cycle;
virus induced;
interferon regulates
Journal Title: Immunity
Year Published: 2019
Link to full text (if available)
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Journal Title: Immunity
Year Published: 2019
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!