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The initial molecular events and the cell type(s) responsible for the development of fibrosis are unclear. Fukushima, Satoh, et al. find that increased expression of the nuclear exosome targeting complex component… Click to show full abstract
The initial molecular events and the cell type(s) responsible for the development of fibrosis are unclear. Fukushima, Satoh, et al. find that increased expression of the nuclear exosome targeting complex component Rbm7 in lung epithelial cells promotes the degradation of the long non-coding RNA NEAT1, impairs DNA repair, and triggers apoptosis. Dying epithelial cells release chemokines that recruit atypical monocytes, which drive tissue fibrosis.
Keywords:
fibrosis;
rbm7 structural;
structural cells;
way control;
neat way;
cells neat
Journal Title: Immunity
Year Published: 2020
Link to full text (if available)
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Journal Title: Immunity
Year Published: 2020
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!