LAUSR

Abstract This work aimed to assess the skin-care effects of dandelion leaf extract (DLE) and dandelion stem extract (DSE), including the phenolic acids identification, antioxidation evaluation, tyrosinase inhibitory and docking simulations study. Results showed that DSEEW (50% ethanol-water extract of DSE) dominated 86.7 mg/g of caffeic acid while DLE was of 2.34 mg/g chologenic acid. DSEEW possessed a similar reducing power with DLEEW (50% ethanol-water extract of DLE), and presented a good performance on anti-DPPH capacity and O2− scavenging despite of being inferior to Vc and DLEEW. Moreover, DSEEW indicated the strongest behavior on UVA and UVB absorption but was weaker than chlorogenic acid. Additionally, DSEEW (IC50 = 0.48 mg/mL) showed the strongest tyrosinase inhibitory, although it was worse than kojic acid (IC50 = 0.063 mg/mL). Molecular docking simulation results indicated caffeic acids in DSEEW presented their inhibitory mechanism mainly via hydrogen bonding interaction with Gly165 and Pro160 of tyrosinase.