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Alternatively spliced natural soluble isoforms of immunomodulatory receptors [cytotoxic T lymphocyte antigen-4 (CTLA-4), 4-1BB, and programmed death-1 (PD-1)/PD-L1] have been overlooked in favor of their cell-surface-bound counterparts that have generated… Click to show full abstract
Alternatively spliced natural soluble isoforms of immunomodulatory receptors [cytotoxic T lymphocyte antigen-4 (CTLA-4), 4-1BB, and programmed death-1 (PD-1)/PD-L1] have been overlooked in favor of their cell-surface-bound counterparts that have generated blockbuster antibodies for the treatment of cancer. We propose that the soluble variants of these receptors contribute to immune regulation and offer potential as targets for immunotherapy.
Keywords:
immunomodulatory receptors;
sight soluble;
hiding plain;
plain sight;
soluble immunomodulatory
Journal Title: Trends in immunology
Year Published: 2018
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Journal Title: Trends in immunology
Year Published: 2018
Link to full text (if available)
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recommendations!