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Targeting Apoptosis Inhibition to Activate Antitumor Immunity.

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A recent study by Rodriguez-Ruiz et al. suggests that inhibition of apoptotic caspases can augment radiation-induced antitumor immunity, independent of type I IFN. Their findings also highlight caspase-independent cytotoxicity in radiation therapy-induced… Click to show full abstract

A recent study by Rodriguez-Ruiz et al. suggests that inhibition of apoptotic caspases can augment radiation-induced antitumor immunity, independent of type I IFN. Their findings also highlight caspase-independent cytotoxicity in radiation therapy-induced antitumor immunity, proposing SLC7A2 as a new putative prognostic marker for breast cancer.

Keywords: immunity; antitumor immunity; targeting apoptosis; activate antitumor; inhibition activate; apoptosis inhibition

Journal Title: Trends in immunology
Year Published: 2019

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