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To keep autoreactive T cells under control in SLE patients, immunosuppressive regimens are used, which can increase susceptibility to bacterial and viral infections. Recently, Katsuyama et al., demonstrated that the… Click to show full abstract
To keep autoreactive T cells under control in SLE patients, immunosuppressive regimens are used, which can increase susceptibility to bacterial and viral infections. Recently, Katsuyama et al., demonstrated that the CD38/NAD/Sirtuin1/EZH2 axis reduces cytolytic CD8+ T cell function and might be targeted to overcome incidence of infections.
Keywords:
histone methyltransferase;
ezh2;
modulating histone;
methyltransferase ezh2;
ezh2 activity;
cd38 modulating
Journal Title: Trends in immunology
Year Published: 2020
Link to full text (if available)
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Journal Title: Trends in immunology
Year Published: 2020
Link to full text (if available)
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recommendations!