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ILC3s: Rhythmic Keepers of Gut Integrity at Mealtime.

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Cyclically, during the day, increased permeability of the intestinal epithelial barrier, allowing nutrient uptake, must be compensated for, to achieve increased protection against potentially harmful components. Seillet et al. demonstrate… Click to show full abstract

Cyclically, during the day, increased permeability of the intestinal epithelial barrier, allowing nutrient uptake, must be compensated for, to achieve increased protection against potentially harmful components. Seillet et al. demonstrate that, upon food intake, enteric neuron-derived VIP promotes anticipatory mucosal immunity by inducing ILC3s to produce protective IL-22.

Keywords: keepers gut; integrity mealtime; rhythmic keepers; ilc3s rhythmic; gut integrity

Journal Title: Trends in immunology
Year Published: 2020

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