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Evidence from genetic, animal, and epidemiologic studies have consistently implicated the serotonin (5-HT) system as an important risk factor for autism spectrum disorder (ASD).1 Hyperserotonemia has been documented in more… Click to show full abstract
Evidence from genetic, animal, and epidemiologic studies have consistently implicated the serotonin (5-HT) system as an important risk factor for autism spectrum disorder (ASD).1 Hyperserotonemia has been documented in more than 25% of pediatric ASD cases.2 Although serotonergic functioning is a plausible and tantalizing component of causal models of ASD pathophysiology, specific mechanisms remain poorly understood.2 Barriers to delineating these mechanisms include the difficulty of disentangling the effects of genetic risks, environmental exposures across development (including gestational exposure to selective 5-HT reuptake inhibitors),3 and the possible interactions between these factors in a population with considerable phenotypic and prognostic heterogeneity.
Journal Title: Journal of the American Academy of Child and Adolescent Psychiatry
Year Published: 2018
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