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differentiation and proliferation and consequently inhibits the replication and assembly of human papilloma virus within the affected cells. Furthermore, acitretin has potent immunomodulatory and apoptotic effects that might play a… Click to show full abstract
differentiation and proliferation and consequently inhibits the replication and assembly of human papilloma virus within the affected cells. Furthermore, acitretin has potent immunomodulatory and apoptotic effects that might play a role in this respect. Recurrence was only reported in 4 patients of the acitretin alone group. This represents a disadvantage of wart therapy by acitretin, which acts through regulation of keratinocyte differentiation and proliferation, a process that might be reversed after discontinuation of therapy. In conclusion, acitretin combined with Candida antigen is a promising, effective, and safe modality for the treatment of multiple recalcitrant warts and is superior to either agent alone.
Journal Title: Journal of the American Academy of Dermatology
Year Published: 2018
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