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identified 5 males exposed to spironolactone in utero without genital feminization, retrospective examination of patient databases may help us identify more cases. Additional human data showing an absence of feminization… Click to show full abstract
identified 5 males exposed to spironolactone in utero without genital feminization, retrospective examination of patient databases may help us identify more cases. Additional human data showing an absence of feminization at acne doses would have a profound impact on how we counsel patients. Given the limited number of animal studies and human cases in this study, there are insufficient data to safely argue that spironolactone does not have the potential to cause feminization of male offspring. However, with more data, this recommendation could change.
Journal Title: Journal of the American Academy of Dermatology
Year Published: 2019
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