LAUSR

BACKGROUND Multiple studies have examined the association between psoriasis and celiac disease (CD). However, these studies have shown conflicting results. OBJECTIVE This study aims to analyze the association between psoriasis and CD. METHODS We conducted a systematic review of the case-control, cross-sectional and cohort studies examining the association between psoriasis and CD in PubMed, Scopus and Cochrane databases. The adjusted effect sizes or crude data were extracted for quantitative analysis. RESULTS Of initially identified 754 citations, 18 studies were included. Random effects meta-analysis found significant odds ratios (ORs) of 2.16 [95% confidence interval(CI), 1.74 to 2.69, 9 studies] for CD in psoriasis patients and 1.8 [95% CI 1.36 to 2.38, 8 studies] for psoriasis in CD patients. We also found a significantly increased risk of new-onset psoriasis in CD [hazard ratio = 1.75, 95% CI 1.58 to 1.93]. Subgroup analyses according to disease severity and geographical region could not be performed due to limited data. CONCLUSIONS This two-way meta-analyses found a significant association between psoriasis and CD. Clinicians should be aware of this association and the psoriasis patients with bowel complaints might benefit from screening for celiac disease through questionnaires or interviews with subsequent gastroenterology consultation.