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BACKGROUND Data regarding the treatment of periorificial dermatitis (POD) with topical calcineurin inhibitors (TCI) in the pediatric population are limited. OBJECTIVE To assess the clinical utility of TCI in pediatric patients with POD. METHODS A retrospective medical record review of all pediatric patients with periorificial dermatitis treated with TCIs was performed. Follow up via telephone was performed to capture missing data. RESULTS One hundred and thirty-two patients met the inclusion criteria. The median age at diagnosis was 4.2 years (IQR 2.3-8.2). Median follow up was 5.2 months (IQR 2.1-11.7). Seventy-two patients had evaluable follow-up data. Of these, 48 (67%) patients were treated with TCI alone, 12 (16.7%) patients were treated with a combination of TCI and topical metronidazole, and 9 (12.5%) patients were treated with a combination of TCI and a systemic antibiotic. Complete response was noted in 68.8% of patients treated with TCI alone, in 75% of patients treated with TCI and metronidazole, and in 77.8% of patients treated with TCI and a systemic antibiotic. Adverse events were rare and mild in severity. CONCLUSION Topical calcineurin inhibitors are an effective therapeutic option for pediatric patients with periorificial dermatitis and were well tolerated in this cohort.