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GW28-e0988 Berberine attenuates cardiac fibrosis via downregulating IGF1R in diabetic rats

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Diabetic cardiac fibrosis increases ventricular stiffness and facilitates occurrence of diastolic and systolic dysfunction. IGF 1R is a key receptor regulating cell growth, survival and differentiation. However, the role of… Click to show full abstract

Diabetic cardiac fibrosis increases ventricular stiffness and facilitates occurrence of diastolic and systolic dysfunction. IGF 1R is a key receptor regulating cell growth, survival and differentiation. However, the role of IGF 1R and its downstream signaling in pathogenesis of diabetic cardiac

Keywords: fibrosis; e0988 berberine; gw28 e0988; cardiac fibrosis; attenuates cardiac; berberine attenuates

Journal Title: Journal of the American College of Cardiology
Year Published: 2017

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