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GW28-e1205 Activin receptor-like kinase 4 deficiency attenuates atrial remodeling and vulnerability to atrial fibrillation induced by pressure overload in mice

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Activin receptor-like kinase 4 (ALK4), a downstream receptor of transforming growth factor-β superfamily, is highly expressed in the mammal heart. We recently reported that ALK4 is upregulated in pressure-overloaded heart… Click to show full abstract

Activin receptor-like kinase 4 (ALK4), a downstream receptor of transforming growth factor-β superfamily, is highly expressed in the mammal heart. We recently reported that ALK4 is upregulated in pressure-overloaded heart and ALK4 haplodeficiency attenuated the pressure overload-induced cardiac

Keywords: pressure overload; like kinase; receptor like; activin receptor; receptor; pressure

Journal Title: Journal of the American College of Cardiology
Year Published: 2017

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