LAUSR

M uch has been learned about the genetic basis of cardiomyopathies (CM). Consequently, contemporary CM classification schemas are based upon molecular genetics (1). Absent from existing genetic classifications, however, is alcoholic cardiomyopathy (ACM), a specific heart muscle disease found in individuals with a longterm history of heavy alcohol consumption (2). There are no specific histological, immunological, or biomarkers for the diagnosis of ACM. A key factor in ruling in ACM is a long-term history of heavy alcohol consumption in the absence of coronary artery disease. A number of pathophysiologic mechanisms have been linked to the development of ACM; however, one of the most important unresolved questions has been related to how certain genetic mutations may influence susceptibility to ACM.