T he paper by Twerenbold et al. (1) in this issue of the Journal builds on multiple previous studies supporting the concept of a 1-h diagnosis to either rule-out or… Click to show full abstract
T he paper by Twerenbold et al. (1) in this issue of the Journal builds on multiple previous studies supporting the concept of a 1-h diagnosis to either rule-out or rule-in acute myocardial infarction (AMI) (2). This protocol is recommended in recent European Society of Cardiology guidelines (3). The strengths of the currently described approach as well as prior validations are the large sample sizes and the concept of assigning patients to 1 of 3 groups: rule-out, observation, or rule-in. It should be noted, however, that the protocol in the study by Twerenbold et al. (1) is not designed to diagnose AMI. Rather, it identifies or excludes
               
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