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GW29-e1374 An EP4 receptor agonist inhibits cardiac fibrosis through activation of PKA signaling in hypertrophied heart

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Cardiac fibrosis is a pathological feature of myocardium of failing heart and plays causative roles in arrhythmia and cardiac dysfunction, but its regulatory mechanisms remain largely elusive. In this study,… Click to show full abstract

Cardiac fibrosis is a pathological feature of myocardium of failing heart and plays causative roles in arrhythmia and cardiac dysfunction, but its regulatory mechanisms remain largely elusive. In this study, we investigated the effects of a novel EP4 receptor agonist ONO-0260164 on cardiac fibrosis

Keywords: heart; fibrosis; receptor agonist; cardiac fibrosis; ep4 receptor

Journal Title: Journal of the American College of Cardiology
Year Published: 2018

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