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Mitochondrial Unfolded Protein Response (UPRmt) Activation in Cardiac Diseases: Opportunities and Challenges.

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As reported by Smyrnias et al. [(1)][1], pre-induction of mitochondrial unfolded protein response (UPRmt) using nicotinamide riboside is sufficient to prevent cardiac dysfunction induced by chronic hemodynamic overload in rodents. These… Click to show full abstract

As reported by Smyrnias et al. [(1)][1], pre-induction of mitochondrial unfolded protein response (UPRmt) using nicotinamide riboside is sufficient to prevent cardiac dysfunction induced by chronic hemodynamic overload in rodents. These findings open up a new avenue for strategies targeting

Keywords: response uprmt; unfolded protein; protein response; mitochondrial unfolded; uprmt activation

Journal Title: Journal of the American College of Cardiology
Year Published: 2019

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