LAUSR

BACKGROUND Suicide is a leading cause of death worldwide. With the increasing volume of administrative health care data, there is an opportunity to evaluate whether machine learning models can improve upon statistical models for quantifying suicide risk. OBJECTIVE To compare the relative performance of logistic regression and single hidden layer feedforward neural network models that quantify suicide risk with predictors available in administrative health care system data. METHODS The modeling dataset contained 3548 persons that died by suicide and 35,480 persons that did not die by suicide between 2000 and 2016. 101 predictors were selected, and these were assembled for each of the 40 quarters (10 years) prior to the quarter of death, resulting in 4040 predictors in total for each person. Logistic regression and single hidden layer feedforward neural network model configurations were evaluated using 10-fold cross-validation. RESULTS The optimal feedforward neural network model configuration (AUC: 0.8352) outperformed logistic regression (AUC: 0.8179). LIMITATIONS Many important predictors are not available in administrative data and this likely places a limit on how well prediction models developed with administrative data can perform. CONCLUSIONS Although the models developed in this study showed promise, further research is needed to determine the performance limits of statistical and machine learning models that quantify suicide risk, and to develop prediction models optimized for implementation in clinical settings.