Highlights • Depressed patients show decreased prefrontal cortex activation compared to controls.• First-degree relatives without depression show intact prefrontal cortex activation.• The prefrontal cortex may be involved in resilience to… Click to show full abstract
Highlights • Depressed patients show decreased prefrontal cortex activation compared to controls.• First-degree relatives without depression show intact prefrontal cortex activation.• The prefrontal cortex may be involved in resilience to depression.• This could also provide preliminary support for targeting this region in treatment.
               
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