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The neural basis of hot and cold cognition in depressed patients, unaffected relatives, and low-risk healthy controls: An fMRI investigation

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Highlights • Depressed patients show decreased prefrontal cortex activation compared to controls.• First-degree relatives without depression show intact prefrontal cortex activation.• The prefrontal cortex may be involved in resilience to… Click to show full abstract

Highlights • Depressed patients show decreased prefrontal cortex activation compared to controls.• First-degree relatives without depression show intact prefrontal cortex activation.• The prefrontal cortex may be involved in resilience to depression.• This could also provide preliminary support for targeting this region in treatment.

Keywords: hot cold; cold cognition; neural basis; basis hot; depressed patients; prefrontal cortex

Journal Title: Journal of Affective Disorders
Year Published: 2020

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