LAUSR

BACKGROUND The etiology of internalising disorders remains poorly understood. Recently, a bottom-up network perspective has suggested mental disorders are best conceptualised as emergent systems, and may be explained by mapping systems of symptoms embedded within a complex biopsychosocial environment. Under this framework, the complex system in which internalising disorders are embedded remains poorly understood. The present research outlines a brief psychosocial system of internalising disorders as a basis for future research. METHODS A Mixed Graphical Model was fitted on 15 psychosocial variables (including depression and anxiety) collected during the Christchurch Health and Development Study, a representative population birth cohort of 1,265 people born in 1977 in Christchurch, New Zealand. RESULTS The model demonstrates that psychosocial risk factors for internalising disorders tend to be inter-related. The psychosocial system accounted for 19.9% of the variance in the diagnostic depression variable, and 5.0% of the variance in diagnostic anxiety. Most variables (10/13) were associated with depression and anxiety either directly or indirectly. LIMITATIONS First, the estimated model is undirected, so causal directions are unspecified except for longitudinal relationships. Second, binary diagnostic variables were used for depression and anxiety, meaning the model does include symptom-level complexity. Third, the model does not account for within-person effects. CONCLUSIONS This exploratory model may serve as a basis for the mapping of greater (bio)psychosocial complexity around internalising disorders. The model concisely demonstrates the need for researchers to "embrace complexity", but also underscores the conceptual scope that is required to do so on a broader (bio)psychosocial level.