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A novel electrochemical determination for the anti-osteoporosis drug (alendronate sodium) and its application for corrosion monitoring of surgical 316 L SS bone implant

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Abstract Low cost and simply produced electrochemical silver nanoparticles modified graphene oxide (SNMGO) sensor was constructed to monitor 1 mM Alendronate sodium (ALN) drug. The corrosion behavior of surgical 316 L stainless… Click to show full abstract

Abstract Low cost and simply produced electrochemical silver nanoparticles modified graphene oxide (SNMGO) sensor was constructed to monitor 1 mM Alendronate sodium (ALN) drug. The corrosion behavior of surgical 316 L stainless steel (SS) as bone implant in simulated body fluid (pH 7.4) coated with a novel nano-composite coating, containing Chitosan (CS), TiO2 nanoparticles (TO) and multi-walled carbon nanotube (CNT) was monitored. Cyclic voltammetry, Differential pulse voltammetry, Potentiodynamic polarization and electrochemical impedance spectroscopy (EIS) measurements were used in ALN electrochemical determination using SNMGO sensor and to detect the corrosion behavior of nano-composite coat (CS/TONP/CNT) in simulated body fluid (SBF). Scanning electron microscope (SEM) and energy dispersive X-Ray analysis (EDX) techniques were done to confirm both sensor and corrosion results.

Keywords: alendronate sodium; electrochemical determination; bone implant; corrosion; surgical 316

Journal Title: Journal of Alloys and Compounds
Year Published: 2017

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