LAUSR

Abstract Copper (II) oxide (CuO) nano-rice like nanoparticles were prepared by a simple chemical precipitation method. Crystal structure, thermal stability, functional group, morphology, and elemental oxidation state of the CuO nano-rice were studied by X-ray diffraction (XRD), thermogravimetric analysis (TGA), Fourier transform infrared spectroscopy (FTIR), high resolution transmission electron microscopy (HR-TEM) and X-ray photoelectron microscopy (XPS). The electrochemical performance was evaluated by cyclic voltammetry, differential pulse voltammetry and chronoamperometry in 0.1 M phosphate buffer solution (pH = 7). Normally dopamine and uric acid are oxidized at similar potential on bare glassy carbon electrode (GCE) but CuO nano-rice/GCE enabled to separate the response and the separation was about 150 mV. The calibration curve shows linear range from 1 to 150 μM for dopamine and 1 to 160 μM for uric acid and limit of detection of dopamine and uric acid were 0.42 μM and 1.2 μM, respectively. The modified electrode was used for practical application for the detection of dopamine and uric acid in the real samples of dopamine injection, human serum and urine samples.