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BACKGROUND Low rates of enrollment and querying of the prescription drug monitoring programs (PDMPs) may be detrimental to the effectiveness of controlling prescription drug misuse. A number of individual-level, organizational, and regulatory factors may affect a community pharmacist's likelihood to query their statewide PDMP. OBJECTIVE To identify predictors of pharmacists' likelihood to query the PDMP. METHODS A self-administered survey was used to collect data from community pharmacists from a national panel. Measures were identified from previous literature assessing provider likelihood to query PDMPs. A principal components analysis of items pertaining to pharmacists' likelihood to query PDMPs was conducted as a data reduction technique to identify underlying dimensions. Multivariable linear regression was conducted to examine relationships between 5 predictor variables (state regulations, practice setting, workload, perceived barriers, and attitude) and the identified components. RESULTS A total of 148 completed survey responses were included for final analysis. The pharmacists'-likelihood-to-query scale comprised 2 components accounting for 71% of the total variance. The 2 components were labeled as higher-risk situations and lower-risk situations. Multivariable linear regression indicated that pharmacists' likelihood to query the PDMP for the higher-risk situations was not statistically significant for any predictor variables. For the lower-risk situations, pharmacists who had a more positive attitude toward the effectiveness of the PDMP were more likely to query it in these situations (unstandardized coefficient = 0.167; P = 0.018). CONCLUSION The factors affecting pharmacists' likelihood to query the PDMP may differ depending on the situations faced by the pharmacist. On the basis of the study results, it seems that pharmacists are currently aware of the importance of checking the PDMP and regularly query it. Overall, the respondent pharmacists had a positive attitude toward the effectiveness of the PDMP, which seems to have a role in their likelihood to query it in lower-risk situations.