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Graphical abstract The hypoxia microenvironment induces the expression of HIF1 and EPAS1 in GCA. During tumor development, the EPAS1 suppresses the expression of HIF1, resulting in the dominant form of… Click to show full abstract
Graphical abstract The hypoxia microenvironment induces the expression of HIF1 and EPAS1 in GCA. During tumor development, the EPAS1 suppresses the expression of HIF1, resulting in the dominant form of HIFs switching from HIF1 to EPAS1. LncRNA ZFAS1 binds to EPAS1, facilitating the HIF1 suppression, EPAS1 up-regulation, and the switching from HIF1 to EPAS1.
Keywords:
long non;
non coding;
hif1 epas1;
coding rna;
epas1;
zfas1
Journal Title: Journal of Advanced Research
Year Published: 2021
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Journal Title: Journal of Advanced Research
Year Published: 2021
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!