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Graphical abstract A proposed model illustrating the therapeutic effect of QCT on AKI. QCT inhibits the expression of ATF3. While ATF3 blocks the system Xc-, and then suppresses GPX4, inducing… Click to show full abstract
Graphical abstract A proposed model illustrating the therapeutic effect of QCT on AKI. QCT inhibits the expression of ATF3. While ATF3 blocks the system Xc-, and then suppresses GPX4, inducing ferroptosis. In another side, ferroptotic cells secrete chemokines like CCL2, CCL7, induce the recruitment of macrophages, and then cause the inflammation in AKI. In summary, QCT ameliorates AKI through the inhibition on ferroptosis and the following inflammation.
Keywords:
quercetin alleviates;
kidney injury;
alleviates acute;
injury inhibiting;
ferroptosis;
acute kidney
Journal Title: Journal of Advanced Research
Year Published: 2021
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Journal Title: Journal of Advanced Research
Year Published: 2021
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!