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Exosomes derived from bone marrow mesenchymal stem cells promote osteosarcoma development by activating oncogenic autophagy

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Highlights • BMSC-Exos promote malignant tumorigenesis and metastasis in OS cells.• BMSC-Exos promotes oncogenic autophagy in OS cells.• BMSC-Exos-mediated autophagy contributes to the BMSC-Exos-induced malignant tumorigenesis metastasis in OS cells. Click to show full abstract

Highlights • BMSC-Exos promote malignant tumorigenesis and metastasis in OS cells.• BMSC-Exos promotes oncogenic autophagy in OS cells.• BMSC-Exos-mediated autophagy contributes to the BMSC-Exos-induced malignant tumorigenesis metastasis in OS cells.

Keywords: derived bone; exosomes derived; bmsc exos; autophagy; oncogenic autophagy

Journal Title: Journal of Bone Oncology
Year Published: 2020

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