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The local and circulating SOX9 as a potential biomarker for the diagnosis of primary bone cancer

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Highlights • The SOX9 expression increased in tumor tissues and peripheral blood of malignant and benign bone tumors.• The protein level of SOX9 is enhanced in malignant bone tumor tissues.•… Click to show full abstract

Highlights • The SOX9 expression increased in tumor tissues and peripheral blood of malignant and benign bone tumors.• The protein level of SOX9 is enhanced in malignant bone tumor tissues.• SOX9 over-expression correlated with tumor severity, grade, invasion feature, poor response to therapy, and recurrence.

Keywords: local circulating; bone; sox9 potential; circulating sox9; biomarker diagnosis; potential biomarker

Journal Title: Journal of Bone Oncology
Year Published: 2020

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