Highlights • Chemotherapy should be suggested to patients with high-risk characteristics.• Chemotherapy should be discussed for tumor downsizing before excisional surgery.• Further studies are needed to identify potential predictive biomarkers… Click to show full abstract
Highlights • Chemotherapy should be suggested to patients with high-risk characteristics.• Chemotherapy should be discussed for tumor downsizing before excisional surgery.• Further studies are needed to identify potential predictive biomarkers in PO patients.
               
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