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Highlights • METTL3 is highly expressed in osteosarcoma.• METTL3 downregulation inhibits metastases of osteosarcoma cells.• m6A regulates osteosarcoma cell activity.• METTL3 modifies TRAF6 activity via m6A.• TRAF6 inhibits the repressive… Click to show full abstract
Highlights • METTL3 is highly expressed in osteosarcoma.• METTL3 downregulation inhibits metastases of osteosarcoma cells.• m6A regulates osteosarcoma cell activity.• METTL3 modifies TRAF6 activity via m6A.• TRAF6 inhibits the repressive effects of sh-METTL3 on osteosarcoma metastases.
Keywords:
upregulation traf6;
mettl3;
m6a dependent;
osteosarcoma;
dependent upregulation
Journal Title: Journal of Bone Oncology
Year Published: 2022
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Journal Title: Journal of Bone Oncology
Year Published: 2022
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!