LAUSR

INTRODUCTION The aim of our study was to assess the association between the Alternate Dietary Inflammatory Index (ADII) and the risk of fracture in a French cohort of women and men older than 50 years. METHODS A total of 15,096 participants were included from the French NutriNet-Santé cohort. The ADII score was calculated at inclusion. Incident low trauma fractures were retrospectively self-reported by participants on a specific additional questionnaire.Multivariate hazard ratio obtained from Cox proportional hazard regression models were used to characterize an association between ADII (in quartiles) and incident low trauma fractures. RESULTS 12,046 participants (7607 (63.2%) women and 4,439 (36.8%) men) were included in our study. For fractures, 806 (10.6%) and 191 (4.3%) low trauma fractures were recorded respectively in women and in men. Mean ADII was -1.23 (+/-3.13) for women and - 0.87 (+/- 3.64) for men. No association was detected between the ADII score and the risk of vertebral fracture (p = 0.21), major osteoporotic fracture (p = 0.93) and any low trauma fracture (p = 0.72) in women nor in men (p = 0.06 for major fracture and p = 0.10 for low trauma fracture) after adjustment for sociodemographic, lifestyle variables and for bone treatments. CONCLUSION This study in postmenopausal women and men older than 50 years from the general population did not show any association between inflammatory dietary pattern measured using the ADII and the risk of incident low trauma fracture.