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ABSTRACT Responsive molecular designs to specific biosignals in microenvironments endow site‐specific functionalities with associated polymers. Thus, the construction of small interfering RNA (siRNA) carriers with functional polymers enables smart programs… Click to show full abstract
ABSTRACT Responsive molecular designs to specific biosignals in microenvironments endow site‐specific functionalities with associated polymers. Thus, the construction of small interfering RNA (siRNA) carriers with functional polymers enables smart programs that are triggered by sequential biosignals in a pathway to the targeted cytosol for effective gene silencing. In this review, we explain rational strategies for the design of functional polymers with responsiveness to biosignals and describe the examples of smart carriers for siRNA delivery. Graphical abstract Figure. No caption available.
Journal Title: Journal of Controlled Release
Year Published: 2017
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