LAUSR

&NA; In this paper, we propose an intravitreal implantable magnetic micropump integrated with micro check valve capable of on‐demand vascular endothelial growth factor receptor (VEGFR)‐targeted drug delivery for the treatment of age‐related macular degeneration, diabetic retinopathy and other eye pathologies characterized by ocular neoangiogenesis. Precise on‐demand drug release is realized by the deflection of the magnetic membrane assembly according to the external magnetic field, and the membrane assembly consists of a thin elastic polydimethylsiloxane (PDMS) membrane and a cylindrical magnetic nanoparticle‐PDMS composite block. Additionally, a micro check valve composed of two PDMS layers was integrated into the micropump to realize a diode‐like one‐directional drug delivery and prevent undesired drug diffusion. For specifically targeting VEGFR and suppression of VEGF‐induced proliferation of microvascular endothelial cells, anti‐Flt1 gold nanocomplexes are synthesized. In vitro and in vivo experiments and quantitative analysis are carried out in order to verify our proposed concept: precise drug release control according to the external magnetic field, targeting to microvascular endothelial cells, and efficient and on‐demand drug delivery from the proposed micropump to the macular area of rabbit's eye. Graphical abstract Figure. No Caption available.