Abstract As a toxic metalloid and nonthreshold carcinogen, arsenic in rice has become a serious concern worldwide due to the risks of chronic human exposure through food. In this study,… Click to show full abstract
Abstract As a toxic metalloid and nonthreshold carcinogen, arsenic in rice has become a serious concern worldwide due to the risks of chronic human exposure through food. In this study, we aimed to assess the variation in arsenic concentration between Sengcu rice planted in a mountainous terrain and lowland commercial rice available for sale in markets around Vietnam. An optimized protocol using microwave-assisted extraction in combination with an HPLC-ICP-MS/MS system was employed for species-specific arsenic extraction from rice samples, and experimental conditions were determined by response-surface methodology for optimal extraction of all arsenic species. Multivariate analysis with generalized linear models was performed to test the hypothesis of intergroup variation in arsenic concentration. Our method yielded high productivity for all arsenic species with >95% accuracy and
               
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