As more manufactured cellular therapies move into clinical use, there is an increasing call for cell culture media supplements that are of high quality, compatible with different cell types, and… Click to show full abstract
As more manufactured cellular therapies move into clinical use, there is an increasing call for cell culture media supplements that are of high quality, compatible with different cell types, and not supply-limited. Human platelet lysate (hPL) is one of several supplements available for manufacturing cell products. Derived from multiple platelet units, hPL contains comparable levels of the same types of growth factors and cytokines found in fetal bovine serum (FBS) and human AB serum. Despite the low risk associated with platelet units screened and tested to the same criteria as transfusable blood units, transmission of infectious agents, notably human viruses, remains a consideration for human platelet-derived products such as hPL. Pooling platelet concentrates can improve hPL consistency and performance, but increases the statistical risk of viral contamination.
               
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