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dHACM: dehydrated human amnion/chorion membrane allograft EPDS: erosive pustular dermatosis of the scalp LI: lamellar ichthyosis INTRODUCTION Erosive pustular dermatosis of the scalp (EPDS) is a disease that tends to affect elderly individuals with history of previous surgery, local trauma, actinic damage, burn injuries, and photodynamic therapy at the involved site. Diagnosis is typically made clinically. The exact etiology is unknown, but impaired immune and reparative properties associated with ultraviolet light damage have been postulated. EPDS is characteristically difficult to treat and has limited therapeutic options that include antibiotics and topical antiinflammatory agents. The review by Starace et al of 20 scalp EPDS cases (mean age, 59 years; range, 1895 years; male/female ratio, 1.8:1) reported an average disease duration of 53 months, with 35% of patients experiencing relapse after treatment cessation. The predisposing factor for the youngpatients (ages 18 and 25) was accidental trauma. With a prevalence of only 16.2 per million, lamellar ichthyosis (LI) is a rare autosomal recessive genodermatosis caused by a transglutaminase-1 mutation. Transglutaminase-1 is a skin barrier enzyme that crosslinks epidermal protein precursors to form impermeable cell envelopes within the stratum corneum. Individuals with LI present at birth with a collodion membrane, which later develops into dark, hyperkeratotic, platelike adherent scales.