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IL: interleukin NBUVB: narrow-band ultraviolet B phototherapy UP: uremic pruritus U remic pruritus (UP) is highly burdensome and difficult to treat. Previous studies implicated interleukin (IL)-31 in the pathogenesis of… Click to show full abstract
IL: interleukin NBUVB: narrow-band ultraviolet B phototherapy UP: uremic pruritus U remic pruritus (UP) is highly burdensome and difficult to treat. Previous studies implicated interleukin (IL)-31 in the pathogenesis of UP. IL-31 expression is upregulated by T-helper 2 cells in several pruritic disorders, including atopic dermatitis and cutaneous T-cell lymphoma. Yet, the role of T-helper 2 or other cytokines in UP has not been fully elucidated. We present a case of UP successfully treated with dupilumab, a fully human monoclonal antibody that targets IL-4 receptor a and blocks signaling of IL-4 and IL-13.
Journal Title: JAAD Case Reports
Year Published: 2019
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