LAUSR

MEC: myoepithelial carcinoma PET: positron emission tomography INTRODUCTION Cutaneous myoepithelial carcinoma (MEC), also referred to as malignant myoepithelial tumor of the skin, is an extraordinarily rare diagnosis, with fewer than 15 cases reported in the scientific literature. These tumors are aggressive, and surgical excision with clear margins is the treatment of choice. However, postsurgical local recurrence and metastases occur in up to 30% and 15% of cases, respectively. Additional therapeutic options are limited; traditional chemotherapy and/or radiation have been described with variable and often disappointing results. Novel treatment modalities are needed for patients who develop local or metastatic disease.We describe a patient with extensiveMEC on the lower portion of the left lower extremity complicated by local recurrence who had a complete response to small-molecule therapy with combined BRAF/MEK inhibition.