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Distinguishing reactive inflammatory dermatoses from lymphoma: 2 cases of severe drug reactions to phenytoin/phenobarbital and rosuvastatin mimicking lymphoma

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CPL: cutaneous pseudolymphomas CTCL: cutaneous T-Cell lymphoma DRESS: drug rash with eosinophilia and systemic symptoms MF: mycosis fungoides PTCL: peripheral T-cell lymphoma INTRODUCTION Cutaneous pseudolymphomas (CPL) are benign lymphoproliferative processes… Click to show full abstract

CPL: cutaneous pseudolymphomas CTCL: cutaneous T-Cell lymphoma DRESS: drug rash with eosinophilia and systemic symptoms MF: mycosis fungoides PTCL: peripheral T-cell lymphoma INTRODUCTION Cutaneous pseudolymphomas (CPL) are benign lymphoproliferative processes secondary to factors such as drug and arthropod reactions, infections, and inflammatory dermatoses that clinically and histologically mimic lymphoma. Similarly, severe cases of drug rash with eosinophilia and systemic symptoms (DRESS) syndrome or drug-induced hypersensitivity syndrome (DIHS) are reported to mimic systemic lymphoma due to blood count abnormalities, lymphadenopathy, and atypical peripheral blood smears. Although challenging at times, distinguishing lymphoma from CPL or a severe drug reaction is critical to avoid potentially unnecessary treatment and assign an appropriate favorable prognosis. We present 2 cases of lymphoma mimickers, initially diagnosed as lymphoma.

Keywords: severe drug; lymphoma; distinguishing reactive; drug; reactive inflammatory; inflammatory dermatoses

Journal Title: JAAD Case Reports
Year Published: 2020

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