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Therapeutic response of facial papules and inflammation in frontal fibrosing alopecia to low-dose oral isotretinoin

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INTRODUCTION First described in 1994 by Kossard, frontal fibrosing alopecia is characterized by scarring alopecia with gradual progressive recession of the frontotemporal portion of the hairline, occurring anywhere from 0.4… Click to show full abstract

INTRODUCTION First described in 1994 by Kossard, frontal fibrosing alopecia is characterized by scarring alopecia with gradual progressive recession of the frontotemporal portion of the hairline, occurring anywhere from 0.4 to 1.7 mm per month. This variant of lichen planopilaris is most commonly found in postmenopausal women and is increasing in prevalence. In addition to hair loss, other features associated with this condition include a band of thin, scarred skin with distinguished vessels, sparse lone vellus hairs, and perifollicular erythema with surrounding fibrosis. Facial papules are a synchronous finding present in 14% of patients with frontal fibrosing alopecia, with profound effects on appearance. The pathogenesis of these lesions is not fully understood and there are currently no established treatments; however, theories involve inflammation of hair follicles, dilated or enlarged sebaceous glands, or a combination of the 2. Herein, we present 3 patients with frontal fibrosing alopecia with progressive hair loss and concomitant facial papules who experienced hair loss stability and significant improvement of facial papules with the use of oral isotretinoin. Severity of scalpdiseasewasgraded 0 to 3 for presence and intensity of perifollicular scale, erythema, and folliculitis.

Keywords: fibrosing alopecia; hair loss; facial papules; frontal fibrosing; oral isotretinoin

Journal Title: JAAD Case Reports
Year Published: 2020

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