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Leukemia cutis in a child with juvenile myelomonocytic leukemia presenting with Sweet syndrome–like lesions and a history of multiple juvenile xanthogranulomas

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JMML: juvenile myelomonocytic leukemia JXG: juvenile xanthogranulomas LCH: Langerhans cell histiocytosis INTRODUCTION Juvenile myelomonocytic leukemia (JMML) is a rare leukemia affecting children. It is known to be associated with multiple… Click to show full abstract

JMML: juvenile myelomonocytic leukemia JXG: juvenile xanthogranulomas LCH: Langerhans cell histiocytosis INTRODUCTION Juvenile myelomonocytic leukemia (JMML) is a rare leukemia affecting children. It is known to be associated with multiple juvenile xanthogranulomas (JXG) and neurofibromatosis type 1 and usually presents before the self-resolution of the JXG. Skin rashes may frequently occur with JMML but are most commonly maculopapular type. Leukemia cutis presenting as a Sweet syndromeelike rash has rarely been reported. We present an interesting and atypical case of JMML in a child with a history of resolved JXG, presenting with leukemia cutis as the first sign of JMML. Histology of the skin rash showed atypical leukemic infiltrates.

Keywords: juvenile myelomonocytic; juvenile xanthogranulomas; juvenile; leukemia cutis; leukemia; myelomonocytic leukemia

Journal Title: JAAD Case Reports
Year Published: 2020

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