LAUSR

ART: antiretroviral therapy CD4: cluster of differentiation 4 INTRODUCTION Talaromycosis, formerly known as penicilliosis, is caused by Talaromyces marneffei (previously known as Penicillium marneffei), an opportunistic fungus that typically infects immunocompromised individuals in Southeast Asia, especially Thailand and Vietnam. The clinical presentation and symptoms of this fungal infection are highly variable; the most common symptoms are fever, fatigue, and characteristic skin lesions. Umbilicated papules with central necrosis are the most common skin lesions observed, which appear as rashes resembling molluscum contagiosum. Other lesions that develop during talaromycosis include subcutaneous nodules, subcutaneous ulcers, cutaneous masses, multiple abscesses, and central necrosis. However, the pathogenesis of T marneffei infection is unclear. Talaromycosis disseminates via the reticuloendothelial system in immunosuppressed individuals, and its severity depends on the degree of immunosuppression. Here, we report a case of talaromycosis in an HIV1 patient with atypical clinical findings which may be a result of immune reconstitution inflammatory syndrome.