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Concurrent pulmonary coccidioidomycosis and immunoglobulin A vasculitis with hemorrhagic bullae

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IgAV: immunoglobulin A vasculitis INTRODUCTION Immunoglobulin A vasculitis (IgAV), formerly known as Henoch-Sch€ onlein purpura, is a smallvessel vasculitis characterized by histopathologic features of IgA1-predominant immune complex deposition primarily in… Click to show full abstract

IgAV: immunoglobulin A vasculitis INTRODUCTION Immunoglobulin A vasculitis (IgAV), formerly known as Henoch-Sch€ onlein purpura, is a smallvessel vasculitis characterized by histopathologic features of IgA1-predominant immune complex deposition primarily in the small-vessel walls of the skin, gastrointestinal tract, and kidneys. This pattern of multiorgan system involvement manifests clinically with classic IgAV presenting as palpable purpura, abdominal pain, hematuria, and arthralgias. IgAV is considered rare among adults, with an estimated annual incidence of 1-1.5/100,000. Antecedent respiratory infection is commonly described and considered a precipitating risk factor for IgAV. The occurrence of IgAV following a fungal infection has not been well documented in the literature or has been underreported. The fungal species of the genus Coccidioides is the pathogenic cause of pulmonary coccidioidomycosis and endemic to southwestern United States. Here, we report a unique presentation of IgAV in an adult patient with extensive hemorrhagic bullae and concurrent pulmonary coccidioidomycosis.

Keywords: hemorrhagic bullae; vasculitis; pulmonary coccidioidomycosis; immunoglobulin vasculitis

Journal Title: JAAD Case Reports
Year Published: 2021

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